Investigation of mitochondrial DNA polymorphisms in patients with hematological malignancy

Aim: Mitochondrial DNA (mtDNA) polymorphisms can be considered as a molecular marker in susceptibility to various types of cancer. In this study, we aimed investigate the potential relationship mtDNA with disease etiopathogenesis patients hematological malignancy.
 Material and Methods: This study was carried out participation 80 diagnosed malignancy healthy individuals Department Medical Genetics, Atatürk University. all participants, 13 polymorphism regions 6 coding genes were investigated by Polymerase chain reaction restriction fragment length (PCR-RFLP) method. SNPs evaluated study; NADH dehydrogenase subunit 5-13704 (C/T), Cytochrome b 15315 12S rRNA 740 (G/A) 680 (T/C), C Oxidase I 7319 -7444 (G/A), II 8252 (C/G), 7660 7975 (A/G), 8014 8113 (C/A), 8152 tRNA lysine 8310 (T/C) identified as.
 Results: ND-5 13704 (C>T) statistically significant malignancies compared controls (p = 0.001). There no difference between other polymorphisms.
 Conclusion: Although findings obtained from suggest that may play role malignancies, large-scale studies are needed determine importance polymorphic region.